Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine
نویسندگان
چکیده
منابع مشابه
Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine
"Funny" (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel subunits. We have investigated the block of f-channels of rabbit cardiac sino-atrial node cells by ivabradine, a novel heart ...
متن کاملInhibition by genistein of the hyperpolarization-activated cation current in porcine sino-atrial node cells.
1 The hyperpolarization-activated cation current (If) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2 Genistein (20-500 microM) decreased If in a dose-dependent manner with an IC50 value of 62.3 microM and a maximum inhibi...
متن کاملتأثیــر نیکــل بر مسدود کردن جریان یونــی گذرای کلسیمــی سلولهای گــره سینوسی ـ دهلیزی دست نخورده و سالم قلب خرگوش
The mammalian sino-atrial node is not a uniform tissue in histological and electrophysiological terms. The differences in ionic currents underlying the regional differences in electrial activity are only just beginning to be understood. One of the ionic currents it is thought to play a role in the center of sino-atrial node for action potential upstroke should be transient Ca+2 current ...
متن کاملThe Wenckebach phenomenon in sino-atrial block.
Disturbances in conduction analogous to those occurring at the atrio-ventricular (A-V) node may be present at the sino-atrial (S-A) junction. When second degree block occurs at the S-A junction, it may adopt the form of the Wenckebach phenomenon. Early descriptions of this arrhythmia were presented by Wenckebach (1906), Rihl (1908), and Wenckebach and Winterberg (1914). There have been relative...
متن کاملPacemaker therapy in sino-atrial block complicated by paroxysmal tachycardia.
Pacemakers were implanted in 10 of 14 patients with dizziness and syncopal episodes of long duration, due to sino-atrial block. Paroxysmal supraventricular tachycardia, notably atrial fibrillation, had occurred in 6 patients. Medical treatment was unsatisfactory in 3 of these and pacemaker therapy was given. This abolished both syncope and paroxysmal tachycardia. Sinoatrial block and supraventr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2002
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.20028593